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No particular dose adjustment recommended when tofacitinib coadministered with strong CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both equally reasonable CYP3A4 and powerful CYP2C19 inhibitors .Edgar and Seidel (1997) investigated the consequences of modafinil on snooze-wake EEG and locomotor exercise in Dwell rats compared wi